- Nourishes the intestinal lining which is coated with a protective barrier, strengthening this first line of immune defense
- Helps protect the body against harmful organisms found in the gut
- Reduces gut inflammation
- Helps with wound healing and reduction of inflammation
- Alleviates gastrointestinal discomfort
- Improves nutrient absorptions
- Reduces the burden on the liver from toxins leaking through the gut wall †
The mucosal barrier—your first-line immune defense—refers to all of the mucous membranes that comprise the primary interface between the external environment and the internal environment of the body. Support Mucosa targets the most critical barrier, that which lines your intestines. This mucosal barrier lets beneficial things into your general circulation and keeps harmful ones out.
To clarify this, an analogy can be made between the earth’s ozone layer and your body’s mucosal barriers. The ozone layer lets the right amount of sunlight through, sustaining life on earth; your mucosal barriers allow nutrients through, sustaining your health. The ozone layer prevents harmful radiation from getting through; the mucosal barriers prevent infectious agents and allergens from invading your body. But just as our planet has a damaged ozone layer, many of us have damaged mucosal barriers. Consequently, we are not protected from harmful substances such as parasites, viruses, and bacteria.
No disease or symptom needs to be present to warrant protecting the mucosal barrier of the intestines; keeping it healthy helps to keep us strong and disease-resistant. Strengthening the gut lining is applicable to relieving and avoiding the impacts of asthma, arthritis, food allergies, ulcers, Crohn's, ulcerative colitis, celiac disease, autoimmune diseases, alcoholism, chronic fatigue, joint pain, migraines, diarrhea, parasitic infections, dysbiosis, candidiasis, multiple sclerosis, and diabetes, all of which can have their origin in harmful substances entering the body from the intestines.
Inflammation—commonly caused by food intolerances and infections—damages these tissues. This image illustrates the shape and components of a healthy mucosal barrier.
In the image below, we see a healthy mucosal lining (left) and one with collapsed tissues—caused by inflammation—on the right. When the finger-like projections called villi collapse visible on the right—harmful organisms are harbored and given a safe place to thrive, while nutrient absorption becomes compromised. The promotion of healing and protection against such damage is paramount to overall health and disease prevention.
Healing of the mucosal barrier can occur when the causes of inflammation are removed and targeted nutrition is delivered. Support Mucosa is specifically formulated to accelerate repair of the mucosal barrier of the gut wall, restoring healthy form and function to damaged tissue. It reduces overall inflammation and supports the liver by preventing toxins from leaking through and damaging this organ, while soothing and restoring the intestinal lining.
A principal component in the formula is the amino acid Glutamine. Glutamine’s ability to heal the mucosal barrier cells and tissue is well known in nutritional science, as is its role in reducing the amount of toxins that penetrate through the barrier into the bloodstream. Glutamine is arguably the most important amino acid given its ability to rebuild tissues and strengthen immune function.
Our First-Line™ Proprietary Blend is a synergistic mix of botanicals that reduces gut inflammation and assists in tissue repair. Combined with the soothing and restorative ingredients quercetin, MSM, bromelain, gamma oryzanol, and N-Acetyl-D-Glucosamine, an amino acid sugar essential for tissue repair, First-Line™ acts as a cohesive healing force. It can improve mucosal barrier integrity, contributing to improved nutrient absorption and protection against foreign agents.
Like each of the BioMatrix formulas, Support Mucosa’s formulation is the result of decades of collective clinical experience with virtually every major line of nutrition product available and his appreciation for the subtle interactions between botanicals. And given the array of ingredients, each with diverse contributions to health, its benefits extend far beyond the primary purpose of healing and strengthening the intestinal wall.
3 Capsules Contain:
Biotin - 1000 mcg
Biotin enters the body through the intestinal mucosa. When a mucosal lining is compromised, supplemental biotin helps to maintain therapeutic levels in circulation. Apart from being a vital cofactor to several enzymes responsible for reducing inflammation, biotin is essential in cell growth through its role in the manufacture of DNA and RNA, the genetic components of cells.1,2
L-Glutamine USP - 425 mg
Glutamine plays a key role in the metabolism, structure, and function of the entire gastrointestinal tract, and its extensive immune system. It is the preferred respiratory fuel for cells called enterocytes and colonocytes. Maintaining the biological activity of these cells is fundamental to maintaining the integrity of the intestinal barrier. In addition, glutamine helps maintain secretory IgA, the antibody that prevents the attachment of foreign substances to mucosal cells.3,4,5,6
Quercetin - 340 mg
Found in only a few dietary sources, quercetin is an antioxidant flavonoid well known for suppressing asthma symptoms. Quercetin prevents the formation of certain inflammatory mediators, thus reducing inflammation and pain in many instances. The mechanism is similar to that of aspirin, but without the side effects. Quercetin also spares vitamin C and stabilizes cell membranes, including those of the mast cells critical to the mucosal immune function.7,8,9
N-Acetyl-D-Glucosamine - 250 mg
Acetyl-D-Glucosamine, a component of intestinal mucous secretions, is deficient in an inflamed bowel, thus reducing the integrity of the mucosal surfaces. Research shows N-Acetyl-D-Glucosamine to be an effective component in the treatment in inflammatory bowel disease. 10,11
Methylsulfonylmethane (MSM) - 160 mg
Experiments with MSM have demonstrated that it binds to the intestinal mucosa. By doing so, it presents a blocking interface between the internal environment of the body and the influences of the external environment. As a result, substances such as allergens and parasites cannot readily bind to the mucosa, toxins are oxidized, and free radicals are eliminated. 12,13
Bromelain (2400 GDU/g) from pineapple - 85 mg
Bromelain is an anti-inflammatory enzyme used to reduce or eliminate pain, aid digestion, accelerate healing, prevent strokes and reduce blood pressure. Derived from pineapple, its primary purpose in Support Mucosa is the control of local inflammation. 14,15
Gamma Oryzanol - 85 mg
Gamma oryzanol, a component of rice bran oil, has been shown to have antioxidant effects on the gastrointestinal mucosa. In one study, gamma oryzanol shows improvement of gastritis in over 62% of the subjects involved.16,17
First-LineT Proprietary Blend - 500 mg
- Deglycyrrhized Licorice Root Extract
- Hawthorne Leaf and Flower Extract
- More potent than berry extract. Well known for its effectiveness at reducing the risk of heart disease, hawthorn berry extract gently dilates the coronary vessels, increasing the supply of arterial blood to the heart. This action enhances circulation and oxygen utilization throughout the mucosal tissues. 20,21
- Milk Thistle Seed Extract (Standardized to Contain 80% Silymarin)
- Eleuthero (Siberian Ginseng) Root Extract(Standardized to Contain 0.8% Eleutherosides)
- Slippery Elm Bark
- Turmeric Root Extract (Standardized to Contain 95% Curcumin)
Natural vegetable capsules, magnesium stearate, and microcrystalline cellulose.
3 capsules 2x daily 15 minutes before meals or as directed by a health professional.
Biotin deficiency in a patient with short bowel syndrome during home parenteral nutrition; N Khalidi, Wesley JR, JG Thoene, Whitehouse WM Jr, and WL Baker; Journal of Parenteral and Enteral Nutrition, Vol 8, Issue 3, 311-314
iotin-mediated protein biosynthesis; R. L. Boeckx and K. Dakshinamurti; Biochem J. 1974 June; 140(3): 549-556.
Glutamine and the preservation of gut integrity.van der Hulst RR, van Kreel BK, von Meyenfeldt MF, Brummer RJ, Arends JW, Deutz NE, Soeters PB. Lancet. 1993 Jul 17;342(8864):186.
Glutamine prevents parenteral nutrition-induced increases in intestinal permeability. Li J, Langkamp-Henken B, Suzuki K, Stahlgren LH. JPEN J Parenter Enteral Nutr. 1994 Jul-Aug;18(4):289-90.
Effects of glutamine on intestinal permeability and bacterial translocation in TPN-rats with endotoxemia. Ding LA, Li JS. World J Gastroenterol. 2003 Jun;9(6):1327-32.
The effects of glutamine on intestinal epithelial cell proliferation in parenterally fed rats. N Mandir,b R A Goodladb. Gut 1999;44:608-614(May).
Dietary flavonol quercetin induces chloride secretion in rat colon; Rainer Cermak, Ursula FÃ¶llmer, Siegfried Wolffram; Am J Physiol; Gastrointest Liver Physiol 275: G1166-G1172, 1998; 0193-1857/98.
Dietary flavonoids and the risk of colorectal cancer; Theodoratou E, Kyle J, Cetnarskyj R, Farrington SM, Tenesa A, Barnetson R, Porteous M, Dunlop M, Campbell H.; Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):684-93.
Intake of specific carotenoids and flavonoids and the risk of gastric cancer in Spain. Garcia-Closas R, Gonzalez CA, Agudo A, Riboli E. Cancer Causes Control. 1999 Feb;10(1):71-5.
Oral polymeric N-acetyl-D-glucosamine and osteoarthritis. Rubin BR, Talent JM, Kongtawelert P, Pertusi RM, Forman MD, Gracy RW. J Am Osteopath Assoc. 2001 Jun;101(6):339-44.
Synergistic effect of N-acetyl-D-glucosamine (NAG) on mitogenic, antigenic and allogeneic stimulation of normal human lymphocytes. Komlos L, Ben-Efraim S, Lewis NJ, Hart J, Halbrecht I. Int J Immunopharmacol. 1984;6(6):593-9.
Lawrence, R.M. Methylsulfonylmethane (MSM): A double-blind study of its use in Degenerative arthritis. International Journal of Anti-Aging Medicine, Summer 1998, I (I); 50.
Usha PR, Naidu MUR. Randomised, double-blind, parallel, placebo-controlled study of oral glucosamine, methylsulfonylmethane and their combination in osteoarthritis. Clin Drug Invest 2004;24(6):353-63.
Seligman B. Bromelain: An anti-inflammatory agent. Angiology 1962;13:508-10.
Kumakura S, Yamashita M, Tsurufuji S. Effect of bromelain on kaolin-induced inflammation in rats. Eur J Pharmacol. 1988; 150:295-301.
Takemoto T, Miyoshi H, Nagashima H. Clinical trial of Hi-Z fine granules (gamma-oryzanol) on gastrointestinal symptoms at 375 hospitals (Japan). Shinyaku To Rinsho 1977;26.
Scavariello EM, Arellano DB. Gamma-oryzanol: an important component in rice bran oil. Arch Latinoam Nutr. Mar1998;48(1):7-
Johnson, B,. and McIssac, R., 1981. Effect of some anti-ulcer agents on mucosal blood flow. British Journal of Pharmacology. 1: 308.
Van Marle, J., et al, 1981. Deglycyrrhized licorice (DGL) and the renewal of rat stomach epithelium. European Journal of Pharmacology. 72: 219-225.
Weihmayr T, Ernst E. Therapeutic effectiveness of Crataegus. Fortschr Med 1996;114:27-9 Nolan.
Leuchtgens H. Crataegus special extract WS 1442 in heart failure, NYHA II. A placebo-controlled randomized double-blind study. Fortschr Med 1993;111:352-4.
Muzes G, et al. Effect of the bioflavonoid silymarin in the in vitro activity and expression of superoxide dismutase (SOD) enzyme. Acta Physical Hung 1991; 78:3-9.
Feher J Lanf I. Nekam K, et al. Effect of the silibinin on the activity and expression of superoxide dismutase in the lymphocytes from patients with chronic alcoholic liver disease. Free Rad Res Commun 1987:3(6):373-77.
Asano K, et al. Effect of Eleutherococcus senticosus extract on human physical working capacity. Planta Med. 1986 Jun;(3):175-7.
Dowling EA, et al. Effect of Eleutherococcus senticosus on submaximal and maximal exercise performance. Med Sci Sports Exerc. 1996 Apr;28(4):482-9.
Duke JA. CRC Handbook of Medicinal Herbs. Boca Raton, FL: CRC Press, 1985, 495-6.
Karn H, Moore MJ. The use of the herbal remedy ESSIAC in an outpatient cancer population. Proc Annu Meet Am Soc Clin Oncol 1997;16:A245.
Arora R, Basu N, Kapoor V, et al. Anti-inflammatory studies on Curcuma longa (turmeric). Ind J Med Res 1971;59:1289-1295.
Brouet I, Ohshima H. Curcumin, an anti-tumour promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthetase in activated macrophages. Biochem Biophys Res Commun 1995;206:533-540.
Repair the gastric mucosa, epithelial lining of the intestines.