Support Adrenals (120 capsules/bottle)

Support Adrenals™

  • Protection against Stress.
  • Support the HPA Axis.
  • Formula Upgraded May 2017!

Price

Quantity

120 Capsules $50.00

Accept no imitations. The quality of raw materials in BioMatrix™ Support Adrenals and its manufacturing process are intricate to its efficacy as a supplement for adrenal gland vitality and stress resistance. 

  • Therapeutic levels of nutrients to support the function of the adrenal glands.
  • Defends against the damaging effects of stress.
  • Helps with glycemic control.
  • Helps in tissue repair and inflammation reduction.
  • Aids in neurological function.
  • Creates a synergistic influence on the adrenal glands that does not hyperstimulate and exhaust already compromised organ function.
  • A vital component of protocols intended to improve HPA axis function.

Formula Upgraded May 2017

With millions of bottles dispensed worldwide for clinical protocols, as well as daily supplement routines, Support Adrenals has held a place at the top of the list for specialty formulas for nearly 20 years. And effective May of 2017, we have improved the formula, to comply with the latest scientific research.

View the Support Adrenals PDF for much more information.

Upgrade Highlights Include:

- Veggie Caps: Capsules are made from natural vegetable sources.

- 5-MTHF: Folate now provided in the form of a proprietary and superior 5-methyltetrahydrofolate (5-MTHF) known as Quatrefolic. This is the most bioavailable source of folate available. With many patients incapable of converting folic acid, this upgrade of folate form is a great improvement.

- Bioflavonoids: Improved sources of bioflavonoids, including addition of citrus peel complex powder.

The Adrenal Glands and Stress

Strong, healthy adrenal glands need support. Everyone experiences stress, so we need to support the physiological system directly responsible for resisting the damage of stress – the HPA Axis. Given unhealthy diets and lifestyles, plus exposure to infectious organisms, toxins and pollutants, our nutrients must be exceptional to be absorbable and provide adequate protection. We all need a daily supplement to help the adrenals work against the odds. Stress causes the adrenal glands to become over-stimulated, often resulting in HPA down-regulation. During periods of demand, essential nutrients are quickly depleted, and hormone synthesis is compromised. You need a formula that replenishes nutrients, while also providing the cells with carefully balanced co-factors to help reduce the load of physical stressors.

Adrenal health is required for production of cortisol and DHEA, hormones involved in HPA function for managing and responding to stress. Support Adrenals is clinically proven to help nourish and support the adrenals by enhancing the body's ability to deal with stressors of all kinds. This synergistic formula of balanced B-vitamins, minerals, adaptogens, bioflavonoids, and supportive co-factors can help in a myriad of ways to improve health and recover from stress-related conditions.

Flagship of the BioMatrix Line

Since its development in 1998, Support Adrenals has earned its place as the flagship of the BioMatrix line. It is the result of a quest to design an affordable, yet highly impactful, daily supplement to support the adrenal glands. For some patients it has helped reduce cravings for coffee or sodas. For others it has been a critical component of therapies intended to correct HPA dysfunction. Thousands have come to know the potent efficacy of this formulation through the resolution of chronic symptoms, such as fatigue, brain fog, allergic sensitivity, and others.

Does Not Hyperstimulate the Adrenal Glands

Knowledgeable health professionals recommend their patients take Support Adrenals daily for its subtle yet powerful mechanisms of action. Unlike many adrenal formulas which can hyperstimulate the glands and exacerbate HPA axis dysfunction, Support Adrenals simply improves the patient's resistance against chronic stress. The adrenals are an integral component of the body's endocrine system. Their relationship to the hypothalamus and pituitary glands, as well as their role in the production of all hormones, including the sex hormones, makes investigation into adrenal-axis health essential to every clinical evaluation.

Support Adrenals – The Formula

Two Capsules of Support Adrenals Contain:

Vitamin C (Ascorbic Acid and Ascorbyl Palmitate) - 100 mg

With enhanced absorption from the complementary bioflavonoids in the formula, this 88/12 blend of water-soluble Ascorbic Acid and fat-soluble Ascorbyl Palmitate adds a synergistic component to the formula – a small amount of high-quality vitamin C that acts to enhance the formula's qualities of tissue repair and allergy resistance, while supporting biosynthesis of corticosteroids and adrenal gland nutrition.1,2

Thiamin (as Thiamin Mononitrate) - 50 mg

A water-soluble vitamin necessary for processing of carbohydrates, fat, and protein. Every cell of the body requires thiamin to form adenosine triphosphate (ATP - energy-carrying molecule found in the cells of all living things) and the nervous system requires thiamin in order to function normally. Studies show that thiamin is directly associated with helping the body to manage stress.3,4

Riboflavin - 50 mg

Besides being essential for other B vitamins to activate their potential, riboflavin acts as a coenzyme in many oxidation-reduction reactions involved with carbohydrate metabolism. 5 Riboflavin is also essential for normal growth and development, cell respiration, regulation of certain hormones, antibody production and the health of the mucous membranes in the digestive tract which serve as the body's first-line immune defense6,7

Niacin (Niacinamide and Niacin) - 50 mg

Niacin plays an important role in ridding the body of toxic and harmful chemicals. It also helps the body make various sex and stress-related hormones in the adrenal glands and other parts of the body. Niacin is effective in improving circulation and reducing cholesterol levels in the blood.8

Vitamin B6 (30 mg as Pyridoxine HCl and Pyridoxine 5'-Phosphate) - 50 mg

Vitamin B6 helps to maintain glucose within a normal range. When caloric intake is low the body requires vitamin B6 to help convert stored carbohydrate or other nutrients to glucose to maintain normal blood sugar levels. Pyridoxine biphosphate is expensive but to ensure B6 uptake in the liver, it is a must-have component in this formulas, as many people have a problem with converting B6. 9

Folate (as as [6S]-5-Methyltetrahydrofolic Acid Glucosamine Salt Quatrefolic) - 400 mcg

Folate participates in many important metabolic processes in the body. It is essential for the normal growth and maintenance of all cells because it acts as a coenzyme for normal DNA and RNA synthesis. It is vital for normal cell division and protein synthesis (both key to efficient bone turnover) and involved in the production of neurotransmitters such as serotonin, which regulate mood, sleep and appetite. Folate deficiency is typically due to factors such as poor diet, alcohol abuse, increased requirements (pregnancy), and malabsorption. A B-vitamin complex is incomplete without folate. Our formula uses the mose absorbable form of 5-MTHF known.10,11

Vitamin B12 (as Cyanocobalamin) - 100 mcg

Besides its quality of aiding in the body’s ability to deal with stress, B12 is necessary for the rapid synthesis of DNA during cell division. This is especially important in tissues where cells are dividing rapidly, particularly the bone marrow tissues responsible for red blood cell formation. B12 is essential for the proper production of blood platelets and red and white blood cells and for the metabolism of nutrients necessary for cell growth.12,13

Biotin - 2000 mcg

When glucose goes intracellular, it must be phosphorylated before it can be metabolically available, and biotin is necessary for phosphorylation. It is extremely important for protecting the adrenal glands from glycemic dysregulation. Biotin acts as a coenzyme during the metabolism of proteins, fats, and carbohydrates. Specifically, it acts as a cofactor for carboxylase reactions that are involved in the synthesis of fatty acids and DNA, energy production, and in the metabolism of branched chain amino acids.14, 15

Pantothenic Acid (as Calcium D-Pantothenate) - 200 mg

Pantothenic acid is essential for the metabolism of food and the synthesis of hormones and cholesterol. The adrenal glands’ production of hormones and nervous system function depends on it. It is necessary for the release of energy from carbohydrates, the synthesis and degradation of fatty acids, and other acetylation reactions. 16,17

Zinc (as Zinc Malate) - 1.5 mg

Zinc has a wide range of functions that contribute to adrenal support. It plays a crucial role in cell growth and division where it is required for protein and DNA synthesis, in insulin activity, in the metabolism of the ovaries and testes, and in liver function. As a component of many enzymes, zinc is involved in the metabolism of proteins, carbohydrates, fats, and energy. The formula’s zinc and copper are based in different carriers that will not compete with one another so they can optimally support pathways that are involved in synthesis of these different hormones. 18

Copper (as Copper Citrate) - .55 mg

A small amount of copper is included to assist in the synthesis of different hormones. Copper is involved in a number of important enzymatic reactions related to the electron-transport chain, as well as serotonin and epinephrine metabolism. It also helps with the formation of elastin as well as collagen to reduce inflammation and assist in tissue repair. The formula’s zinc and copper are based in different carriers that will not compete with one another so they can optimally support pathways that are involved in synthesis of these different hormones. 19,20

PABA (Para-Aminobenzoic Acid) - 75 mg

Used to improve protein breakdown,it is helpful in red blood cell formation as well as assisting the manufacture of folic acid in the intestines. Importantly for the adrenal glands, PABA has been reported to enhance the effects of cortisone and rejuvenate the glandular system.21

Citrus Peel Bioflavonoid Complex - 50 mg

This bioflavonoid complex assists vitamin C in supporting healthy collagen, is essential for proper absorption of vitamin C, and prevents vitamin C from being destroyed in the body by oxidation. Bioflavonoids help to reduce inflammation and aid in tissue repair. 22,23

Choline Bitartrate - 20 mg

Needed for the proper transmission of nerve impulses from the nerve endings to the target organ. It is an essential nutrient used by the peripheral nervous system to produce acetylcholine, a major brain/motor neuron neurotransmitter that facilitates the transmission of impulses between neurons. Supporting the nervous system to protect the adrenal glands is paramount to any stress management protocol.24

Inositol - 50 mg

Inositol is a part of the vitamin B-complex needed to metabolize glucose and for proper formation of cell membranes. Inositol affects nerve transmission and helps transport fats throughout the body.25

Eleuthero Root Extract - 50 mg

Adaptogen proven to increase mental performance and physical working capacity in humans. Siberian Ginseng contains eleutherosides responsible for the adaptogenic properties of the plant. The eleutherosides include a range of glycosides with aromatic alcohol aglycones. The glycosides act on the adrenal glands, helping to prevent adrenal hypertrophy and excess corticosteroid production in response to stress. The eleutherosides additionally help reduce the exhaustion phase of the stress response and return the adrenals to normal function faster. Support Adrenals’ ginseng extract results from a two-step repercolation at low temperature, with ethanol/water ratios and pH stabilization that prevent hydrolysis of the eleutherosides. 26,27

Rosemary Leaf Extract - 36 mg

A very potent antioxidant. The most important constituents of rosemary are carnosol, carnosic acid, caffeic acid - compounds with powerful antioxidant activity. The rosmarinic acid in rosemary leaf increases the production of prostaglandin E2 and reduces the production of leukotriene B4 in human white blood cells, and inhibits the complement system. This makes rosemary a strong anti-inflammatory agent as well. Support Adrenals’ rosemary leaf extract results from a two-step repercolation at low temperature, with ethanol/water ratios and pH stabilization that prevent hydrolysis of the powerful compounds within. 28,29

Naringin (extracted from Grapefruit) - 36 mg

Naringin is a flavonoid found in grapefruits, and gives the fruit its characteristic bitter flavor. Naringin has antioxidant, anti-carcinogenic and cholesterol lowering activity. Studies show that naringin reduces LDL oxidation and can help to prevent hypercholesterolemia. It also helps to negate food and chemical reactions in the liver. Naringin plays an important role in protecting the adrenal glands from chronic stress. 30

Rutin - 10 mg & Hesperidin Methylchalcone - 36 mg

Rutin and hesperidin are complementary components of the formula’s bioflavonoid group and function synergistically with Vitamin C to help maintain healthy capillaries, form collagen in connective tissue, heal wounds, and to support a healthy immune system. They act together to reduce the release of inflammatory compounds by stabilizing mast cells. 31

DHEA (Dehydroepiandrosterone, micronized) - 8 mg & Pregnenolone (micronized) - 8 mg

A small amount of DHEA and pregnenolone with a low-dose, physiological action for long-term maintenance.32,33

Other ingredients

Veggie capsule

Suggested Use

2 capsules with breakfast and lunch is generally recommended. Hormone lab testing may be considered to fine-tune dosing.

References

  1. Patak P, Willenberg HS, Bornstein SR. Vitamin C is an important cofactor for both adrenal cortex and adrenal medulla. Endocr Res. 2004 Nov;30(4):871-5.

  2. Chen H, Tappel AL. Vitamin E, selenium, trolox C, ascorbic acid palmitate, acetylcysteine, coenzyme Q, beta-carotene, canthaxanthin, and (+)-catechin protect against oxidative damage to kidney, heart, lung and spleen. Free Radic Res. 1995 Feb;22(2):177-86.

  3. Lakaye B, Makarchikov AF, Wins P, Margineanu I, Roland S, Lins L, Aichour R, Lebeau L, El Moualij B, Zorzi W, Coumans B, Grisar T, Bettendorff L.Human recombinant thiamine triphosphatase: purification, secondary structure and catalytic properties. Int J Biochem Cell Biol. 2004 Jul;36(7):1348-64.

  4. Kelly GS. Nutritional and botanical interventions to assist with the adaptation to stress. Alt Med Rev. 1999; 4(4):249-265.

  5. Riboflavin and adrenal cortex. Nutr Rev. 1973 Mar;31(3):95-6.

  6. Riboflavin and adrenal cortical metabolism. Nutr Rev. 1960 Jul;18:221-2.

  7. Barthelemy H, Chouvet B, Cambazard F. Skin and mucosal manifestations in vitamin deficiency. J Am Acad Dermatol. 1986 Dec;15(6):1263-74.

  8. Carlson LA.Nicotinic acid: the broad-spectrum lipid drug. A 50th anniversary review. J Intern Med. 2005 Aug;258(2):94-114.

  9. Laber B, Maurer W, Scharf S, Stepusin K, Schmidt FS. Vitamin B6 biosynthesis: formation of pyridoxine 5'-phosphate from 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose-5-phosphate by PdxA and PdxJ protein. FEBS Lett. 1999 Apr 16;449(1):45-8.

  10. Fenech M, Aitken C, Rinaldi J. Folate, vitamin B12, homocysteine status and DNA damage rate in young Australian adults. Carcinogenesis 1998;19:1163–71.

  11. Russel RM. A minimum of 13,500 deaths annually from coronary artery disease could be prevented by increasing folate intake to reduce homocysteine levels. JAMA 1996;275:1828–9.

  12. Ray JG, Cole DE. Vitamin B12 and homocysteine. CMAJ. 2005 Nov 22;173(11):1359-60.

  13. Nowak M, Swietochowska E, Wielkoszynski T, Marek B, Kos-Kudla B, Szapska B, Kajdaniuk D, Glogowska-Szelag J, Sieminska L, Ostrowska Z, Koziol H, Klimek J. Homocysteine, vitamin B12, and folic acid in age-related macular degeneration. Eur J Ophthalmol. 2005 Nov-Dec;15(6):764-7.

  14. Zempleni J, Mock DM. Biotin biochemistry and human requirements. J Nutr Biochem 1999;10:128–38.

  15. Somer E. The Essential Guide to Vitamins and Minerals. New York: Harper, 1995, 70–2.

  16. Somer E. The Essential Guide to Vitamins and Minerals. New York: Harper, 1995, 70–2.

  17. Fidanza A. Therapeutic action of pantothenic acid. Int J Vitam Nutr Res 1983;suppl 24:53–67 [review].

  18. Leonardi R, Zhang YM, Rock CO, Jackowski S. Coenzyme A: back in action. Prog Lipid Res. 2005 Mar-May;44(2-3):125-53. Epub 2005 Apr 20. Review.

  19. Prasad AS. Zinc in human health: an update. J Trace Elem Exp Med 1998;11:63–87.

  20. Nolan, K., "Copper Toxicity Syndrome", J. Orthomolecular Psychiatry, 12:4, p.270-282.

  21. D.M. Danks. Copper Deficiency in Humans. In: "Biological Roles of Copper." CIBA Foundation Symposium-79. Exerpta Medica, Amsterdam, 1980.

  22. Wiesel LL, Barritt AS, Stumpe WM. The synergistic action of para-aminobenzoic acid and cortisone in the treatment of rheumatoid arthritis. Am J Med Sci 1951;222:243–8.

  23. Vinson JA, Bose P. Comparative bioavailability to humans of ascorbic acid alone or in a citrus extract. Am J Clin Nutr 1988;48:601–4.

  24. Kuo SM. Antiproliferative potency of structurally distinct dietary flavonoids on human colon cancer cells. Cancer Lett 1996;110:41–8.

  25. Wurtman RJ, Hefti F, Melamed E. Precursor control of neurotransmitter synthesis. Pharmacol Rev. 1981; 32:315-335.

  26. Levine J, Barak Y, Gonzalves M, et al. Double-blind, controlled trial of inositol treatment of depression. Am J Psychiatry; 152:792–4, 1995.

  27. Kelly GS. Nutritional and botanical interventions to assist with the adaptation to stress. Alt Med Rev. 1999;4(4):249-265.

  28. Harkey MR, Henderson GL, Gershwin ME, Stern JS, Hackman RM. Variability in commercial ginseng products: an analysis of 25 preparations. Am J Clin Nutr. 2001;73:1101-1106.

  29. Castleman M. The Healing Herbs. New York: Bantam Books, 1991, 452–6.

  30. Aqel MB. Relaxant effect of the volatile oil of Rosmarinus officinalis on tracheal smooth muscle. J Ethnopharmacol 1991;33:57–62.

  31. DG Bailey, PhD, JMO Arnold, MD, HA Strong, PhD, C Munoz, MD, and JD Spence, MD. Effect of grapefruit Juice and naringin on nisoldipine pharmacokinetics. CLIN PHARMACOL THER 1993;54:589-94.

  32. Guardia T, Rotelli AE, Juarez AO, Pelzer LE. Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat. Farmaco 2001 Sep;56(9):683-7.

  33. Disorders of androgen synthesis--from cholesterol to dehydroepiandrosterone. Med Princ Pract. 2005;14 Suppl 1:58-68. Review.

  34. Cerny I, Pouzar V, Budesinsky M, Bicikova M, Hill M, Hampl R. Synthesis of [19- 2H3]-analogs of dehydroepiandrosterone and pregnenolone and their sulfates. Steroids. 2004 Mar;69(3):161-71.